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Radiation therapy is a standard treatment for limbs soft tissue sarcomas. External-beam radiotherapy (EBRT) has been the most commonly used modality. Modern EBRT techniques such as conformal image-guided intensity modulated radiotherapy (IGRT/IMRT) could decrease the incidence of complications. Preoperative versus postoperative EBRT has been a controversial topic for years but the neoadjuvant schedule is henceforth gaining ground. Newer drug-EBRT combinations are also being prospectively assessed. EBRT must be personalized according to the histological subtype, the tumor site and the benefit/risk ratio, which is best appreciated by a multidisciplinary surgical and oncological team in a specialized center in the management of soft-tissue sarcomas.