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Copenhagen, Denmark
Onsite/Online

ESTRO 2022

Session Item

Breast
Poster (digital)
Clinical
Pattern of care for brain metastasis from breast cancer over the past 10 years in Korea
Jae Sik Kim, Korea Republic of
PO-1219

Abstract

Pattern of care for brain metastasis from breast cancer over the past 10 years in Korea
Authors:

Jae Sik Kim1, Kyubo Kim2, Wonguen Jung2, Kyung Hwan Shin1, Seock-Ah Im3, Hee-Jun Kim4, Yong Bae Kim5, Jee Suk Chang5, Jee Hyun Kim3, Doo Ho Choi6, Yeon Hee Park7, Dae Yong Kim8, Tae Hyun Kim8, Byung Ock Choi9, Sea-Won Lee9, Suzy Kim10, Jeanny Kwon11, Ki Mun Kang12, Woong-Ki Chung13, Kyung Su Kim14, Ji Ho Nam15, Won Sup Yoon16, Jin Hee Kim17, Jihye Cha18, Yoon Kyeong Oh19, In Ah Kim1

1Seoul National University College of Medicine, Department of Radiation Oncology, Seoul, Korea Republic of; 2Ewha Womans University College of Medicine, Department of Radiation Oncology, Seoul, Korea Republic of; 3Seoul National University College of Medicine, Department of Internal Medicine, Seoul, Korea Republic of; 4Chung-Ang University College of Medicine, Department of Internal Medicine, Seoul, Korea Republic of; 5Yonsei University College of Medicine, Department of Internal Medicine, Seoul, Korea Republic of; 6Sungkyunkwan University School of Medicine, Department of Radiation Oncology, Seoul, Korea Republic of; 7Sungkyunkwan University School of Medicine, Department of Internal Medicine, Seoul, Korea Republic of; 8National Cancer Center, Proton Therapy Center, Goyang, Korea Republic of; 9The Catholic University of Korea, Department of Radiation Oncology, Seoul, Korea Republic of; 10Seoul Metropolitan Government Seoul National University Boramae Medical Center, Department of Radiation Oncology, Seoul, Korea Republic of; 11Chungnam National University College of Medicine, Department of Radiation Oncology, Daejeon, Korea Republic of; 12Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Department of Radiation Oncology, Changwon, Korea Republic of; 13Chonnam National University Medical School, Department of Radiation Oncology, Hwasun, Korea Republic of; 14Dongnam Institute of Radiological and Medical Sciences, Department of Radiation Oncology, Busan, Korea Republic of; 15Pusan National University School of Medicine, Department of Radiation Oncology, Busan, Korea Republic of; 16Korea University Medical College, Department of Radiation Oncology, Seoul, Korea Republic of; 17Keimyung University School of Medicine, Department of Radiation Oncology, Daegu, Korea Republic of; 18Yonsei University Wonju College of Medicine, Department of Radiation Oncology, Wonju, Korea Republic of; 19Chosun University Medical School, Department of Radiation Oncology, Gwangju, Korea Republic of

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Purpose or Objective

We aimed to investigate manifestations and patterns of care for patients with brain metastasis (BM) from breast cancer (BC) and compared their overall survival (OS) from 2005 through 2014 in Korea.

Material and Methods

We retrospectively reviewed 600 BC patients with BM diagnosed between 2005 and 2014. The median follow-up duration was 12.5 months. We categorized the patients into three groups according to the year when BM was initially diagnosed [group I (2005–2008), 98 patients; group II (2009–2011), 200 patients; and group III (2012–2014), 302 patients]. 

Results

Over time, the median age at BM diagnosis increased by 2.2 years (group I, 49.0 years; group II, 48.3 years; and group III, 51.2 years; p=0.008). The percentage of patients with extracranial metastasis was 73.5%, 83.5%, and 86.4% for group I, II, and III, respectively (p=0.011). The time interval between BC and BM was prolonged in patients with stage III primary BC (median, 2.4 to 3 years, p=0.029). As an initial brain-directed treatment, whole-brain radiotherapy alone decreased from 80.0% in 2005 to 41.1% in 2014. Meanwhile, stereotactic radiosurgery or fractionated stereotactic radiotherapy alone increased from 13.3% to 34.7% during the same period (p = 0.005). The median OS for group I, II, and III was 15.6, 17.9, and 15.0 months, respectively, with no statistical significance.

Conclusion

The manifestations of BM from BC and the pattern of care have changed from 2005 to 2014 in Korea. However, the OS has remained relatively unchanged over the 10 years.