Clinical outcome with radiotherapy in management of Craniopharyngioma: A Single institute experience
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Abstract
Clinical outcome with radiotherapy in management of Craniopharyngioma: A Single institute experience
Authors: Subhash Gupta1, Haresh KP1, Vibhay Pareek2, Mansi Barthwal2, Devangana Bora1, Prashanth Giridhar1, Bharti Devnani3, Pramod Kumar Julka1
1IRCH, AIIMS, Radiation Oncology, New Delhi, India; 2National Cancer Institute, AIIMS, Radiation Oncology, New Delhi, India; 3AIIMS, Radiation Oncology, Jodhpur, India
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Purpose or Objective
Craniopharyngioma are rare tumours of the sellar region and commonly
seen in pediatric and young adult patient population. The optimal management Data
on demographic details, symptomatology, treatment and response is limited from
the Indian sub-continent. In this study, we assess the demographics and pattern
of care in management of craniopharyngioma
Material and Methods
Patients
included in the retrospective analysis were those who presented to the
neuro-oncology clinic under radiation oncology department after surgery between
January 2003 and December 2020. The patient records were reviewed and the
demographic, treatment details and outcomes were retrieved using predesigned
proforma. Kaplan-Meier
estimates of OS and univariate and multivariate Cox proportional hazards
regression analyses were performed. Propensity score–matched analyses were
performed to further control for baseline confounders.
Results
A
total of 65 patients were assessed retrospectively from the medical records of
our institute. With a median follow-up of 96 months, the median age of
presentation was 16.4 years (Range 2 – 36 years). Majority of the patient
population were males (65.6%) and the commonest symptom at presentation was
headache and adamantinomatous type being the commonest histopathology among the
patients. The complete response rate was
91% and remaining 9% had a partial response post treatment. At the time of last
analysis, the 8-year local control rate was 87% and overall survival was 93%.
The median radiation dose delivered was 50.4Gy in 28 fractions and no grade 3
or 4 toxicities were documented. On univariate analysis, age was a major factor
predicting the local control with better outcomes in the pediatric population.
However, no association with other patient or disease characteristics were
associated with significance in survival outcomes.
Conclusion
Craniopharyngioma are effectively treated with a combination of surgery
and radiation therapy and a multimodality treatment forms a cornerstone in the
management. Radiation therapy is a safe treatment option especially in
pediatric population with excellent survival outcomes and reduced toxicities.