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Vienna, Austria

ESTRO 2023

Session Item

Saturday
May 13
08:00 - 08:40
Strauss 1
Survey results and systematic review of the dosimetry information in papers on SBRT clinical trials
Patricia Diez, United Kingdom
Teaching Lecture
Physics
08:20 - 08:40
Recommendation on the technical and dosimetric data to be included in stereotactic body radiation therapy clinical trial publications based on a systematic review
Pietro Mancosu, Italy
SP-0006

Abstract

Recommendation on the technical and dosimetric data to be included in stereotactic body radiation therapy clinical trial publications based on a systematic review
Authors:

Mirjana Josipovic1, Nick Hardcastle2, Enrico Clementel3, Manuela Gober4, Lotte Wilke5, David Eaton6, Victor Hernandez7, Jordi Saez8, Gregory Smyth9, Laure Vieillevigne10, Nuria Jornet11, Pietro Mancosu12

1Rigshospitalet, -, Copenhagen, Denmark; 2Peter MacCallum Cancer Centre, -, Sydney, Australia; 3EORTC , -, Brussels, Belgium; 4Landesklinikum Wiener Neustadt , -, Vienna, Austria; 5Universitätsspital Zürich , -, Zürich , Switzerland; 6Guy's and St Thomas' Hospital , -, London , United Kingdom; 7Hospital Universitari Sant Joan de Reus, -, Tarragona, Spain; 8Hospital Clínic of Barcelona , -, Barcelona , Spain; 9The Institute of Cancer Research , -, London, United Kingdom; 10Institut du Cancer-Avignon Provence , -, Avignon, France; 11Hospital de la Santa Creu i Sant Pau , -, Barcelona, Spain; 12IRCCS Humanitas Research Hospital , -, Milan, Spain

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Abstract Text


Purpose: The application of stereotactic body radiotherapy (SBRT) is continuously increasing and is no longer restricted to academic centres thanks to the results of phase II-III clinical trials. The ability to replicate clinical trial outcomes into routine practice depends on the ability to reproduce the technical procedures used in the clinical trial. However, due to large variability in SBRT planning, delivery and reporting between the institutions, interpretation of published SBRT studies can be challenging. This study reports the results of the ESTRO 2021 physics workshop on harmonization and standardization of SBRT planning and delivery. In this work, we evaluated the technical data reported in SBRT clinical trial publications with the aim of: (i) determine if sufficient detail was provided to replicate the treatment and results in routine clinical practice and (ii) provide recommendation on the technical components of patient treatments that should be included when reporting SBRT clinical trial results.

Methods: A working group (WG) of 12 medical physicists performed a systematic review focusing treatment planning, delivery and reporting parameters in phase II and III SBRT trials (PROSPERO systematic review database #CRD42021286365). The data extraction included information on dose (irradiation technique, patient specific QA, constrains) and IGRT/imaging (margins, motion management, and immobilization). Following data extraction and review, members of the WG voted on whether each collected data field was ‘mandatory’, ‘useful’, or ‘not required’ when reporting a clinical trial. The requirement was based on the required technical information to be able to treat patients at a given centre according to how patients were treated in a given clinical trial.

Results: Twenty-two papers were extracted from the initial 2124 reviewed papers. A large variability was found in the reported data, as well as the lack of data for reproducing these treatments in clinical practice. Figure 1 reports the frequency of whether each technical component has been reported in a way that can be reproduced in routine clinical practice. We provided a recommendation on the technical components of patient treatments that should be included when reporting SBRT clinical trial results.


Figure 1: Frequency of whether each technical component has been reported in a way that can be reproduced in routine clinical practice.

Conclusions: Our recommendation could help improve the reproducibility of the technical data included in the main SBRT clinical trial document and increase harmonization of SBRT practice.