Vienna, Austria

ESTRO 2023

Session Item

Monday
May 15
16:30 - 17:30
Strauss 1
Flash and proton measurement
Florian Amstutz, Switzerland;
Tony Lomax, Switzerland
Proffered Papers
Physics
17:00 - 17:10
Silicon carbide detectors for dosimetry and monitoring of UHDR beams for FLASH radiotherapy
Giuliana Milluzzo, Italy
OC-0930

Abstract

Silicon carbide detectors for dosimetry and monitoring of UHDR beams for FLASH radiotherapy
Authors:

Giuliana Milluzzo1, Simone Capaccioli2,3, Damiano Del Sarto4, Fabio Di Martino5,4, Maria Cristina D'Oca6,7, Giuseppe Felici8, Maurizio Marrale9,10, Luigi Masturzo11, Elisabetta Medina12, Marco Montefiori3, Fabiola Paiar13,14, Jake Harold Pensavalle11, Enrico Sangregorio15, Anna Vignati16, Massimo Camarda17, Francesco Romano9

1Istituto Nazionale di Fisica Nucleare, Sezione Catania, Catania, Italy; 2Università di Pisa , Centro Pisano ricerca e implementazione clinica Flash Radiotherapy (CPFR@CISUP) Presidio S. Chiara, ed. 18 via Roma 67 , Pisa, Italy; 3Università di Pisa, Department of Physics Largo B. Pontecorvo 3 I-57127 , Pisa, Italy; 4Università di Pisa, Centro Pisano ricerca e implementazione clinica Flash Radiotherapy (CPFR@CISUP) Presidio S. Chiara, ed. 18 via Roma 67, Pisa, Italy; 5Fisica Sanitaria, Azienda Ospedaliero Universitaria Pisa AOUP, ed.18 via Roma 67, Pisa, Italy; 6National Institute of Nuclear Physics (INFN), Catania Division, Via Santa Sofia, 64, 95123 , Catania, Italy; 7University of Palermo, Department of Physics and Chemistry "Emilio Segrè" Viale delle Scienze Edificio 18, Palermo, Italy; 8SIT-Sordina, . , Aprilia, Italy; 9National Institute of Nuclear Physics (INFN), Catania Division, Via Santa Sofia, 64, Catania, Italy; 10University of Palermo, Department of Physics and Chemistry "Emilio Segrè", Viale delle Scienze Edificio 18, Palermo, Italy; 11Azienda Ospedaliero Universitaria Pisa AOUP, Fisica Sanitaria, ed.18 via Roma 67, Pisa, Italy; 12Università degli Studi di Torino , Physics Department via P. Giuria 1, 10125, Torino, Italy; 13Università di Pisa, Centro Pisano ricerca e implementazione clinica Flash Radiotherapy (CPFR@CISUP) Presidio Santa Chiara ed. 18 via Roma 67 , Pisa, Italy; 14Università di Pisa, Radiation Oncology Unit, Department of Translational Research, Pisa, Italy; 15Università degli Studi di Catania, Dipartimento di Fisica, Via Santa Sofia 64, Catania, Italy; 16Università degli Studi di Torino, Physics Department via P. Giuria 1, 10125, Torino, Italy; 17SenSiC, DeliveryLab, Villigen, Switzerland

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Purpose or Objective

A big effort is addressed on developing alternative detectors able to maintain a linear response  at ultra-high dose-rate (UHDR), as ionization chambers suffer of ion recombination effects. Moreover, in the perspective of a clinical translation, QA measurements under the FLASH conditions imply the delivery of a huge amount of total dose per day, leading  to significant radioprotection issues, especially if beam profiles are scanned with a single point like detector. In this framework, the use of high radiation hard silicon carbide (SiC) detectors for the beam dosimetry and online monitoring of UHDR beams has been experimentally investigated in the perspective to design and develop a 2D SiC array allowing the measurement of the transversal beam profiles on a single shot basis.

Material and Methods

A collaboration involving the INFN Catania Division and the start-up ST-Lab (Catania) has been established for developing a new generation of SiC detectors of different thicknesses (0.2- 20 um thick) and areas (1-10 mm2), including a never explored configuration based on ultra-thin “free standing membranes” where the bulk substrate is removed. The response of the SiC detectors, was studied with UHDR electron beams using the SIT Sordina ElectronFLASH accelerator available at the Centro Pisano for Flash Radio Therapy (CPFR) in Pisa, Italy. The measurements were carried out placing the different types of SiC detectors in air at the position of 9 MeV build-up (13 mm water equivalent depth) and measuring the charge collected by the SiC detectors with a Keithley 6517A electrometer coupled with an external RC circuit (R=2KΩ , C=1uF) needed to avoid saturation of the electrometer due to the extremely high peak current (up to 100’s of mA). Doses per pulse (DPP) ranging from few cGy up to 5 Gy were delivered on a pulse duration ranging from 1 us up to 4 us (up to 1.2 MGy/s  instantaneous dose rate).

Results

Figure 1 (left) shows an optimal linearity (R2=0.999) of the SiC detector (5x5 mm2 and 10x10 mm2, 10 um thick) response as a function of the DPP. Alanine detectors were employed as a dose rate independent reference for the measurement of the delivered dose. Pulse shape time measurements at high time resolution (ns) were also performed (Figure 1, right), by connecting the detectors to a fast oscilloscope showing the high sensitivity of such detectors to the eventual intra-pulse small variations of the instantaneous dose rate which is one of the crucial parameters for the preclinical investigations of the FLASH effect. 

Conclusion

The results clearly demonstrated the dose-rate independence of  newly developed SiC detectors at FLASH regime and their capability of providing the intra-pulse real-time monitoring of the instantaneous dose rate  at high time resolution. Moreover, both large area SiC sensors and 2D configurations with high spatial resolution can be easily realized representing a unique a promising perspective for the QA and dosimetry measurements of UHDR beams.