Quality of life among men who have sex with other men treated for anal cancer: Impact of HIV status
PO-1090
Abstract
Quality of life among men who have sex with other men treated for anal cancer: Impact of HIV status
Authors: MAURO|, Geovanne Pedro(1)*[geovanne95@gmail.com];Vasconcelos|, Karina Gondim Moutinho da Conceição (2);Carvalho|, Heloisa de Andrade(1);
(1)University of Sao Paulo, Radiology and Oncology, Sao Paulo, Brazil;(2)Instituto do Cancer do Estado de Sao Paulo - icesp, Radiotherapy, Sao Paulo, Brazil;
Show Affiliations
Hide Affiliations
Purpose or Objective
In oncology studies, retrospective data usually identify MSM patients among people living with HIV (PLWHIV). Our aim is to describe the impact of HIV status on quality of life (QoL) and sexual function among MSM patients treated for anal cancer using validated QoL assessments questionnaires on PLWHIV population in a single institution cohort.
Material and Methods
Single institution prospective cohort of MSM who were treated for anal cancer and selected according to the HIV status. Patients were accrued between November 2015 and May 2019. All patients were treated with IMRT technology radiotherapy with concurrent chemotherapy as by the ACTII randomized trial guideline. Questionnaires were applied before treatment, at treatment end and then at 3, 6 and 12 months of follow-up. No patient had detectable virus load and all had CD4+ cell count high enough to receive chemotherapy.
Results
From 40 men that were assessed, 19 accepted to participate in the study and completed the requested questionnaire. From these, 15 PLWHIV are the subject of this analysis. Median age was 54.6 years and all patients had undetectable viral load and mean CD4+ count of 561 cells/mm3. With a median follow-up of 19.1 months, mean overall survival, systemic progression free survival, survival free of local relapse and colostomy-free survival were, respectively, 25.3, 24.0, 21.6 and 23.1 months. No median value was reached. Results of HIV/AIDS targeted QoL instrument showed that PLWHIV patients experienced drops on QoL sensitive to the instruments. The sexual function domain of this questionnaire showed the same pattern identified with IIEF questionnaire in the general cohort, showing that patients reach worse SF, reaching pre-treatment levels at six months after treatment.
Conclusion
Instruments direct aimed for PLWHIV can give better information on this group of patients. Our results show that patients treated for anal cancer that are MSM have a deterioration of their SF and that must be kept in mind so the best treatment can be given to this population, especially those that live with HIV.