Session

Overview: The recent renaissance of interest towards ultra-high dose rate and spatially fractionated delivery techniques has raised new biological and physics challenges to be addressed for their clinical implementation. In this symposium, first, the evolution of spatially fractionated radiation therapy from photons to charged particles will be presented. Then, the symposium continues with the honorary ESTRO member presentation of Natalka Suchowerska discussing the particular biochemical mechanisms underlying the radiation response highlighting the need of focusing on specific biological rather than physically targets. To conclude, the state of art for ultra-high dose rate electron beam and synchrotron X-rays microbeam will be presented as well as the remaining issues to solve for their clinical transfer.