Date & Time :  9 June 2026 | 15:00–16:00 CEST | Online

 

 

This teaching webinar for radiation oncologists addresses current radiobiological concepts and practical clinical applications in the field of reirradiation. The session begins with an update on BED, EUD, EQD2 and related metrics, clarifying their contemporary relevance and limitations in modern radiation oncology. Treatment planning considerations for both reirradiation and repeat irradiation will be discussed, focusing on dose accumulation, organ-at-risk constraints, and plan optimization strategies. The program includes a dedicated case-based discussion on glioblastoma reirradiation across varying fractionation schemes (single, three, and five fractions), highlighting essential clinical and radiobiological factors to consider. Finally, the webinar provides a comprehensive overview of repeat and reirradiation strategies for brain metastases, covering patient selection, toxicity profiles, and evolving clinical evidence.

 

Chairs

• Nicolaus Andratschke, University of Zurich, Switzerland

• Raffaella De Pietro, EORTC, Brussels

 

Panellists

• Maximilian Niyazi, Tübingen University Hospital, Germany
• Giuseppe Minniti, UPMC Rome & Sapienza University Rome, Italy
• Jan Unkelbach, University of Zurich, Switzerland
• Denise Bernhardt, TU Munich, Germany

 

Programme

15:00 – 15:05 | Introduction by Chair

15:05 – 15:15 | BED, EUD, EQD2, et all – what’s the current status? Speaker: Maximilian Niyazi

15:15 – 15:25 | Radiotherapy planning considerations for reirradiation and repeat irradiation - Speaker: Jan Unkelbach

15:25 – 15:35 | Reirradiation of Glioblastoma (1, 3, 5 treatments) – case discussion and general background what’s important to keep in mind - Speaker: Giuseppe Minniti

15:35 – 15:45 | Repeat and Reirradiation of Brain Mets – general overview - Speaker: Denise Bernhardt

15:45 – 15:55 | Panel discussion and audience Q&A

15:55 – 16:00 | Conclusions and wrap-up

 

Key Learning Objectives

What skills and insights will participants gain from attending this webinar?

• Participants will understand the radiobiological principles underlying BED, EUD, and EQD2 and evaluate their relevance in the context of modern hypofractionation and stereotactic regimens.
• Participants will be able to formulate treatment planning strategies for reirradiation and repeat irradiation, including dose summation methods and organ-at-risk tolerance considerations.
• Participants will be able to select appropriate reirradiation fractionation schemes (single, 3, or 5 fractions) for recurrent glioblastoma based on tumor location, prior dose, and patient-specific factors while recognizing critical neurotoxicity risks.
• Participants will understand the current evidence and practical workflow for reirradiation of brain metastases following prior whole-brain radiotherapy or stereotactic radiosurgery.