Online

ESTRO 2020

Session Item

Clinical track: Lower GI (colon, rectum, anus)
9306
Poster
Clinical
23:00 - 23:00
Innovative technologies in treatment of patients with squamous cancer of the anal canal
PO-1086

Abstract

Innovative technologies in treatment of patients with squamous cancer of the anal canal
Authors: Glebovskaya|, Valeria(1)*[oncovalery@mail.ru];Sergey|, Tkachev(1);Nazarenko|, Alexey(1);Bulychkin|, Petr(1);
(1)National Medical Research Center of Oncology named by N.N. Blokhin, Radiation Oncology Department, Moscow, Russian Federation;
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Purpose or Objective

The increase in number of cured patients with squamous cell anal carcinoma and the quality of life is directly related to improvement of radiotherapy departments’ technical equipment in oncological clinics. Most precise determination of tumor volume using modern diagnostic methods, which give a possibility to make maximum impact on the tumor and identified affected lymph nodes while limiting dose to organs at risk, and also reduction of chemoradiotherapy course duration are ones of the main goals of radiotherapy technologies’ improvement.

Material and Methods

During the period from 2000 to 2015, 301 patients with squamous cell anal carcinoma, stage T1-4N0-3M0-1, were treated by radiation therapy with 2DRT, 3DCRT, or IMRT in a total dose of 50-60 Gy in combination with chemotherapy.

Results

The use of IMRT with MRI in comparison with 3DCRT resulted in an increase of frequency of complete tumor response (at the time of first diagnostic control)  up to 67.5% (p = 0.071); reduction of frequency of interruptions in the treatment course up to 48% (p = 0.005); significantly increased the 3-year overall survival rate to 92.9% (p = 0.05), distant  metastases-free survival - 91% (p = 0.049), with a trend of improvement in locoregional control - 89.9% (p = 0.179).

Conclusion

The use of radiation therapy in its modern version has reduced the rate of interruptions in the treatment course, has achieved high immediate and long-term oncological results, has reduced the frequency and severity of early and late chemoradiation complications.