Clinical results of particle therapy in patients with postoperative recurrence of rectal cancer
PO-1092
Abstract
Clinical results of particle therapy in patients with postoperative recurrence of rectal cancer
Authors: Waki|, Takahiro(1)*[takahiro.waki1201@gmail.com];Okimoto|, Tomoaki(2);Terashima|, Kazuki(2);Niwa|, Yasue(1);Jin|, Dongcun(1);Demizu|, Yusuke(2);Katsui|, Kuniaki(3);Tokumaru|, Sunao(2);Kanazawa|, Susumu(3);
(1)Tsuyama Chuo Hosptal, Radiology, Tsuyama-shi, Japan;(2)Hyogo Ion Beam Medical Center, Radiology, Tatsuno-shi, Japan;(3)Okayama University Hospital, Radiology, Okayama-shi, Japan;
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Purpose or Objective
To evaluate the outcome of particle therapy in patients with postoperative locoregional recurrence of rectal cancer at Hyogo Ion Beam Medical Center.
Material and Methods
Retrospective analysis of 59 patients who received 74 Gy (RBE) / 37 fr between March 2004 to March 2014 was performed. There were 42 males and 17 females, with a median age of 63 years (range, 37-79). Proton and carbon ion therapy were used for 48 and 11 patients, respectively. Seven patients had the history of distant metastasis prior to particle therapy, and all metastasis were under control by local therapies. Median serum CEA and CA19-9 level at the end of irradiation were 5.7 ng/ml (range, 0.8-465.0) and 16.9 U/ml (range, 0.2-334.3), respectively.
Results
The median follow-up period was 26.7 months (range, 4.6-104.7 months). The 2-year overall survival (OS), progression-free survival (PFS), and local control (LC) rates were 83.0%, 35.2%, and 64.4%, respectively. In multivariate analysis using the Cox proportional hazards model, lower serum CEA and CA19-9 level at the end of irradiation and no history of distant metastasis were significantly favorable factors for OS and PFS. Lower serum CA19-9 level at end of irradiation was a significantly favorable factor for LC. There were no differences between carbon ions and protons on OS, PFS, LC. The late adverse effects of ≥Grade 3 were observed in 9 patients.
Conclusion
Particle therapy using protons or carbon ion has shown to achieve survival benefit not inferior to surgery.